Current Data Collections
Psychiatric Connectomics
👤 Avram Holmes, PhD — PI, Rutgers University, RWJ Medical School Department of Psychiatry
Thomas Yeo, PhD — PI, National University of Singapore
Justin Baker, PhD — Co-PI, Harvard Medical School, McLean Hospital
Aims
Objective: Establish connectome signatures, or “fingerprints”, that co-vary with cognition, negative valence systems, and social functions in healthy and clinical samples, dissecting their associated genetic and cellular bases.
Questions to address: 1) To what extent can brain function predict symptom profiles (cognition, negative valence, and social functions) across transdiagnostic cohorts, revealing the presence of clinical subgroups
2) Can a predictive modeling approach establish network profiles that precede longitudinal change
3) Do cell type profiles recapitulate functional network organization in the general population
4) Do these cellular associates of network function reveal genomic signatures that are co-heritable with psychiatric illness risk